2021 年 13 巻 1 号 p. 8-12
Little is known about the influence of the phototoxicity of dental materials. Light-cured composite resin is polymerized by intense light irradiation in the oral cavity, although it is temporary. There has been no report on the biological influence of intense light irradiation on oral cavity tissue. We previously confirmed that camphorquinone (CQ) contained in light-cured composite resin for dental use as a photosensitizer decreased the cell viability in a light-irradiated group compared with that in a non-irradiated group within a concentration range from 0.313 to 2.5 mg/mL using 3T3 cells specified in the OECD phototoxicity guidelines. In this study, we investigated the influence of light irradiation in actual light-cured composite resin mixed with Bis-GMA contained as a base monomer, not the influence of CQ alone, on the influence of light irradiation on cell viability. It was confirmed that similarly to CQ alone, the cell viability decreased in the state mixed with Bis-GMA.
