Carbonate Ion Induced Calcification Using Biomimetic Enzymes with Active Reaction Center of Carbonc Anhydrase

抄録

In this study, we synthesized two types of biomimetic enzyme analogues, a macromolecules-type, and a surface modified particle type. Both of the biomimetic enzymes promoted selective hydroxyapatite formation and carbonate ion induction. Therefore, the biomimetic enzymes can be used to 1) accelerate the calcification reaction, 2) control the crystal phase, and 3) incorporate carbonate ion in hydroxylapatite. These properties can allow us to develop several carbonated hydroxyapatite materials that have potential in applications such as bone tissue engineering.