Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles

Koichi NAKAMURA; Ko NAKANISHI; Yosuke BANDO; Akira HASEBE; Atsushi HYONO; Shigeaki ABE; Ken-ichiro SHIBATA; Yasuhiro YOSHIDA; Junichiro IIDA; Yasutaka YAWAKA

doi:10.11344/nano.9.29

ORIGINAL ARTICLES

Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles

Koichi NAKAMURA, Ko NAKANISHI, Yosuke BANDO, Akira HASEBE, Atsushi HYONO, Shigeaki ABE , Ken-ichiro SHIBATA, Yasuhiro YOSHIDA, Junichiro IIDA, Yasutaka YAWAKA

Author information

Koichi NAKAMURA
Department of Dentistry for Children and Disabled Person,
Ko NAKANISHI
Department of Orthodontics, Fucalty of Dental Medicine,
Yosuke BANDO
Department of Orthodontics, Graduate School of Dental Medicine,
Akira HASEBE
Department of Oral Molecular Microbiology, Fucalty of Dental Medicine, Hokkaido University, Sapporo
Atsushi HYONO
Department of Materials Chemistry, National Institute of Technology, Asahikawa College, Asahikawa
Shigeaki ABE Corresponding author
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine, Hokkaido University, Sapporo
Ken-ichiro SHIBATA
Department of Oral Molecular Microbiology, Fucalty of Dental Medicine, Hokkaido University, Sapporo
Yasuhiro YOSHIDA
Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine, Hokkaido University, Sapporo
Junichiro IIDA
Department of Orthodontics, Fucalty of Dental Medicine,
Yasutaka YAWAKA
Department of Dentistry for Children and Disabled Person,

Keywords: nanoporous silica particles, epigallo catechin gallate, glass ionomer cement, controlled drug-release behavior

JOURNAL FREE ACCESS

2017 Volume 9 Issue 1 Pages 29-34

DOI https://doi.org/10.11344/nano.9.29

Details

Abstract

In this study, nanoporous silica particles (NPS) were synthesized and their controlled drug-release behavior was investigated. The NPS were mixed with glass ionomer cement (GIC), which is a common dental material. Epigallocatechin gallate (EGCG) was charged into the samples as a model drug. Samples were immersed into distilled water; then, the supernatant was analyzed every day using a UV-visible spectrophotometer to observe EGCG-release behavior. GIC containing NPS can release EGCG for more than one week, whereas specimens without NPS released it for only a few days. This suggests that NPS has an excellent ability for sustained drug-release.

Corresponding author

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