Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles
Koichi NAKAMURAKo NAKANISHIYosuke BANDOAkira HASEBEAtsushi HYONOShigeaki ABEKen-ichiro SHIBATAYasuhiro YOSHIDAJunichiro IIDAYasutaka YAWAKA
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2017 Volume 9 Issue 1 Pages 29-34

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Abstract

In this study, nanoporous silica particles (NPS) were synthesized and their controlled drug-release behavior was investigated. The NPS were mixed with glass ionomer cement (GIC), which is a common dental material. Epigallocatechin gallate (EGCG) was charged into the samples as a model drug. Samples were immersed into distilled water; then, the supernatant was analyzed every day using a UV-visible spectrophotometer to observe EGCG-release behavior. GIC containing NPS can release EGCG for more than one week, whereas specimens without NPS released it for only a few days. This suggests that NPS has an excellent ability for sustained drug-release.

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© 2017 Nano Biomedical Society
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