Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
Cell Survival Rate under Mixing Condition on Nano Titanium Dioxide or Zinc Oxide with Three Types of Dental Metal Ions
Tsubasa SHIRAIKoichi IMAI
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2017 Volume 9 Issue 1 Pages 35-40


The safety of mixed materials for the body cannot be evaluated based on the mean of the safety data of the individual component materials in many cases, and the toxicity level may markedly vary when the mixture is influenced by a synergistic effect. Many recent commercial products are mixed with nanomaterials. Nanomaterials are incorporated into cells through special mechanisms, such as phagocytosis, but only a few studies have reported the evaluation of mixtures with nanomaterials. Thus, we investigated changes in the cytotoxicity levels of dental metals (Ag, Cu, and Pd ions) in a mixture with a very small non-toxic amount of nano titanium dioxide or nano zinc oxide by measuring the cell survival rate. The cytotoxicity levels slightly changed in the presence of a very small amount of nano titanium dioxide or nano zinc oxide compared with those in the absence of the nanomaterials, although the changes were not marked. Investigation from the perspectives of various fields including other nanomaterials is expected.

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© 2017 Nano Biomedical Society
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