Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles

Koichi NAKAMURA; Ko NAKANISHI; Yosuke BANDO; Akira HASEBE; Atsushi HYONO; Shigeaki ABE; Ken-ichiro SHIBATA; Yasuhiro YOSHIDA; Junichiro IIDA; Yasutaka YAWAKA

doi:10.11344/nano.9.29

ORIGINAL ARTICLES

Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles

Koichi NAKAMURA, Ko NAKANISHI, Yosuke BANDO, Akira HASEBE, Atsushi HYONO, Shigeaki ABE , Ken-ichiro SHIBATA, Yasuhiro YOSHIDA, Junichiro IIDA, Yasutaka YAWAKA

著者情報

キーワード: nanoporous silica particles, epigallo catechin gallate, glass ionomer cement, controlled drug-release behavior

ジャーナルフリー

2017 年 9 巻 1 号 p. 29-34

DOI https://doi.org/10.11344/nano.9.29

詳細

抄録

In this study, nanoporous silica particles (NPS) were synthesized and their controlled drug-release behavior was investigated. The NPS were mixed with glass ionomer cement (GIC), which is a common dental material. Epigallocatechin gallate (EGCG) was charged into the samples as a model drug. Samples were immersed into distilled water; then, the supernatant was analyzed every day using a UV-visible spectrophotometer to observe EGCG-release behavior. GIC containing NPS can release EGCG for more than one week, whereas specimens without NPS released it for only a few days. This suggests that NPS has an excellent ability for sustained drug-release.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）