Bone Induction by α-tricalcium Phosphate Microparticle Emulsion                    Containing Simvastatin

Akito TATEYAMA; Akihito KATO; Hirofumi MIYAJI; Erika NISHIDA; Yasuhiko IWASAKI; Syuji FUJII; Kohei KAWAMOTO; Kanako SHITOMI; Tomokazu FURIHATA; Kayoko MAYUMI; Tsutomu SUGAYA

doi:10.11344/nano.9.69

ORIGINAL ARTICLES

Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

Akito TATEYAMA, Akihito KATO, Hirofumi MIYAJI, Erika NISHIDA, Yasuhiko IWASAKI, Syuji FUJII, Kohei KAWAMOTO, Kanako SHITOMI, Tomokazu FURIHATA, Kayoko MAYUMI, Tsutomu SUGAYA

著者情報

Akito TATEYAMA
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Akihito KATO
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Hirofumi MIYAJI
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Erika NISHIDA
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Yasuhiko IWASAKI
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan
Syuji FUJII
Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan
Nanomaterials Microdevices Research Center, Osaka Institute of Technology, Osaka, Japan
Kohei KAWAMOTO
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Kanako SHITOMI
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Tomokazu FURIHATA
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Kayoko MAYUMI
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Tsutomu SUGAYA
Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan

キーワード: α-tricalcium phosphate (TCP), bone tissue engineering, bone paste, water-oil emulsion, simvastatin

ジャーナルフリー

2017 年 9 巻 2 号 p. 69-76

DOI https://doi.org/10.11344/nano.9.69

詳細

抄録

To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects.

Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）