2025 Volume 40 Issue 1 Pages 41-46
Objective: 10 cases of gastric mucosa-associated lymphoid tissue (MALT) lymphoma were observed in medical checkup.
Methods and Results: Between April 2016 and March 2024, 10 cases with no gastrointestinal symptoms were detected (the average age of 10 cases was 59.7, the male to female ratio was 7:3). Under endoscopy, the appearance of MALT lymphoma varied, including superficial, ulcerative, mass-forming types. Histologically, the diffuse infiltration of mild atypical neoplastic lymphoid cells, which often infiltrate into gastric glands causing the destruction of epithelial cells (lymphoepithelial lesion), were observed in these cases. MALT lymphoma cells exhibited CD20+, CD79α+. 1 case of Helicobacter pylori-negative received H. pylori eradication therapy. 3 cases of H. pylori-negative and 5 cases post H. pylori eradication were treated with radiotherapy.
Conclusions: Here, we reported 10 cases of gastric MALT lymphoma detected by endoscopy during routine medical checkup. Recently, an increase in the incidence of H. pylori-negative gastric MALT lymphoma has been reported. Therefore, careful follow-up of cases in remission is necessary.
