Abstract
Biomarkers are important indicators for various diseases. The development of easy method for detecting biomarkers is required for preservation and early diagnosis. In this context, we developed a biomarker detection system using supramolecular gels. Generally, it is very difficult to recognize a specific biomarker by supramolecular assemblies. To realize the selective sensing of a specific biomarker, we hybridized supramolecular gels with enzymes. The enzymes embedded in the supramolecular gels could work and induce the decomposition of gel fibers and gel－sol transition, in response to a specific biomarker. Furthermore, encapsulation of the signal amplification system for improvement of detection sensitivity in the gels allows us to detect biomarkers in human blood plasma at the diagnostic concentration level.
