カルシウム透過性AMPA型グルタミン酸受容体と神経膠芽腫
キーワード:
calcium-permeable AMPA type glutamate receptor,
glioblastoma,
invasive growth behavior,
gliomagenesis
2015 年 22 巻 2 号 p. 22-29
詳細
2015 年 22 巻 2 号 p. 22-29
Glioblastoma cells release and exploit glutamate for proliferation and migration by autocrine or paracrine loops through Ca2+ -permeable・-amino-3-hydroxy-5-methyl-4-isoxazolepropionate -type glutamate receptors (CP-AMPAR). Here we show the molecular mechanism behind glioblastoma cells expressing CP-AMPAR, and refer to its role for gliomagenesis.
