Stem cell-based gene therapy for malignant gliomas

Abstract

Treatment of malignant gliomas is extremely difficult because of their invasive nature. Stem cells have been extensively investigated as vehicles for gene delivery to malignant gliomas because of their inherent tumor-tropic properties. Here we present current trends in stem cell-based gene therapy against malignant gliomas and discuss the possibilities and problems for translating experimental findings into clinic studies.