A case report of Growing Teratoma Syndrome in a Patient with Intracranial Mixed Germ Cell Tumor

Abstract

Intracranial growing teratoma syndrome (IGTS) is a rare clinical entity, which presents with enlarging teratoma masses occurring during or after systemic chemotherapy for the treatment of nonseminomatous germ cell of the testis (NSGCT), with normalised tumor markers. We report a patient who experienced IGTS during systemic chemotherapy and radiotherapy.

The patient is a 12years old boy and the location of tumor was pineal area. Mixed Germ Cell Tumor was diagnosed by biopsy and tumor markers (AFP and HCG). Chemotherapy and radiotherapy are performed after biopsy and endoscopic third ventriculostomy(ETV). Despite the decrease in tumor marker levels to normal values, MRI examination revealed that tumor size increased. Total tumor resection are performed and histological analysis of tumor tissue only revealed a mature teratoma.