Morphological Change of Head and Neck Tumor Cells by Apoptosis

Abstract

Apoptosis or programmed cell death plays a key role in maintenance of the steady state in continuously renewing tissues. However, the apoptosis of head and neck tumor has not been investigated. In this study, we studied morphological change of head and neck tumor-derived cell lines (KB, KBrc, HSC-2,3,4), induced by anti Fas antibody in vitro. Apoptosis, which was determined by light and electoro morphological changes occured during culture for 1 to 2 days. Most ofthe cells underwent apoptosis was greatly enhanced when tumor cells were cultured in the presence of the interferon-γ. However, the antitumor effect of anti Fas antibody on tumor cell were different from cell lines used.