Print ISSN : 0917-074X
ISSN-L : 0917-074X
パーキンソン病とその関連疾患における経頭蓋超音波検査を用いた黒質高輝度変化のGray Scale Medianを応用した半定量的評価の検討
沼尾 文香鈴木 圭輔竹川 英宏宮本 雅之宮本 智之岩波 正興高田 悦雄平田 幸一
ジャーナル フリー

2012 年 25 巻 1 号 p. 7-12


Objective: Hyperechogenicity in the midbrain substantia nigra (SN) on transcranial sonography (TCS) images has been reported in Parkinson’s disease (PD). We used a semi-quantitative evaluation method, the Gray Scale Median, to quantify echogenic changes.
Subjects: Hospitalized patients with PD (n = 7) or Parkinsonian syndrome (PS) (n = 7) and in-hospital control subjects (n = 6) were included. The PS group consisted of cases of progressive supranuclear palsy (n = 3), multiple system atrophy (n = 2), and corticobasal degeneration (n = 2).
Methods: The subjects were evaluated using TCS. The SN was identified within the midbrain and the areas with echogenic signals were circled and measured. Next, echogenic signals in the SN and dorsal midbrain (DM) were converted into gray scale using Photoshop software (Adobe Systems Inc., Tokyo, Japan) and the median gray scale values of the SN and DM were obtained using a histogram. The SN-to-DM ratio was calculated.
Results: Compared with the PS and control groups, the PD group had an increased SN-to-DM ratio and a larger SN hyperechogenic area. The SN-to-DM ratio correlated positively with the SN hyperechogenic area.
Conclusion: A semi-quantitative evaluation of echogenic signal changes using the SN-to-DM ratio may be useful for the objective evaluation of SN signal changes.

© 日本脳神経超音波学会 2012
前の記事 次の記事