抄録
This study was conducted to evaluate the effects of probucol and pravastatin on intima-media thickness (IMT) in patients with hypercholesterolemia. Alterations of IMT (ΔIMT) at carotid bif urcations were measured after treatment with probucol or pravastatin during a mean follow-up period of 23 months in 20 patients. ΔIMT was significantly lower in the 10 patients treated with probucol (-0.128±0.121mm/y) than in the 10 patients treated with pravastatin (0.091±0.043mm/y) (p<0.0001) . There was a significant correlation between serum levels of HDL cholesterol and ΔIMTs after treatment with probucol (r=0.720, p=0.0190) . These results suggest the inhibitory as well as regressive effects of probucol on carotid atherosclerosis in comparison with pravastatin.
