抄録
Diabetes Mellitus is an important factor in aggravation of atherosclerosis. Common carotid arterial wall properties and hemodynamics in healthy (H) and in diabetes mellitus (DM) groups were measured by an ultrasonic quantitative flow measurement system. Each group was divided into 3 classes according to age, class 1: 45-54, class 2: 55-64 and class 3: 65-74 y.o.
Wall properties examined were vessel diameter (D) and stiffness parameter (β), while hemodyamics examined were maximum blood velocity (Vbmax), blood flow volume (Qb), and carotid and cerebral vascular resistance (Zo) . These indices, measured before and after a 5-year interval, were compared. Statistical analysis: the results were analyzed using student-t test; p-value less than 5% was defined as significant (*) .
Results obtained were as follows: The increases in D (mean value) were -1.1, 4.3, 0.2% in the H group and 6.3*, 5.2*, 4.5*% in the DM group in classes 1, 2 and 3 respectively. The increases in mean/βwere 2.9, 3. 0, 9.1% in the H and 23.7*, 13.0 24.3*% in the DM group. Vbmax decreased -7.4, 6.9, -0.6% in the H group and 18.6*, 9.3*, 14.3*% in the DM group. Qb decreased 0.5, -3.1, 0.6% in the H group and 3.4, 2.0, 6.8% in the DM group.
The changes in each index after 5 years were larger and more significant in the DM group as compared with the H group. In conclusion, atherosclerosis of the carotid and cerebral arteries would aggravate more rapidly in the DM group than in H group from middle age together with dilatation, stiffening and hemodynamic disorders.
