原著
実験的頭部外傷後のラット海馬CA1ニューロンにおける過興奮に対する軽度低体温の効果
2006 年 29 巻 1 号 p. 38-43
詳細
2006 年 29 巻 1 号 p. 38-43
The effect of mild hypothermia on neuronal activity in hippocampal CA1 was studied by using optical recording techniques in rats which had suffered from fluid percussion injury (FPI) at 7 days after trauma. After lateral impact, neuronal hyperexcitability was commonly induced in the bilateral hippocampal CA1 areas. Mild hypothermia was induced within 30 minutes after FPI for 1 hour or 3 hours. With the mild therapeutic hypothermia, neuronal hyperexcitability was significantly suppressed when compared with case of FPI models those without hypothermia. These results suggest that mild hypothermia for at least 1 hour suppresses the neuronal hyperexcitability induced by moderate lateral FPI.
