原著（牧野賞受賞）
頭部外傷と酸化ストレス：フリーラジカルモニタリングとその臨床応用について
2008 年 31 巻 1 号 p. 1-8
詳細
2008 年 31 巻 1 号 p. 1-8
Recent clinical trials and experimental studies have demonstrated that oxygen free radicals and reactive oxygen species (ROS) have important roles of various neuronal conditions. Neurotrauma is also related to oxidative stress strongly. There are some biomarkers to evaluate ROS generation. On the other hand, the kinetics of free radical in itself has not been evaluated in clinical setting because of difficulty in measurement. Recently, we developed novel free radical (alkoxyl radical: RO･) monitoring using electron spin resonance (ESR) method. We evaluated blood RO･ levels in patients with neurotrauma and other conditions. RO･ levels in patients with neurotrauma were higher than that of healthy volunteers. We also proved that edaravone administration (30 mg i.v) and brain hypothermia therapy suppressed RO･ levels in patients with neurotrauma.
In conclusion, direct free radical monitoring by ESR method is useful to evaluate oxidative stress in patients with neurotrauma in clinical setting.
