瀰漫性軸索損傷患者における脳梁傷害部位の検討：臨床的特徴と転帰

抄録

Object: Previous studies have shown a relationship between lesions and clinical outcome among patients with diffuse axonal injury. However, there have been a few numbers of data about insulted anatomical points of corpus callosum. The aim of this study is to know the clinical characteristics and outcome were affected by the type of lesion of the corpus callosum in patients with diffuse axonal injury.

Methods: A retrospective, single-institution study involving 37 Japanese patients with diffuse axonal injury among 304 patients with blunt head trauma was conducted between July 2003 and May 2009. Bivariate analyses were performed to evaluate clinical characteristics and outcome according to each type of lesion of the corpus callosum in patients with diffuse axonal injury.

Results: Among the 37 patients with diffuse axonal injury, 19 had corpus callosum injury. Patients with lesion of corpus callosum had a lower one-year extended Glasgow outcome scale in patients with diffuse axonal injury. There were five, seven, and seven patients, with lesions of genu, body, and splenium of the corpus callosum, respectively. Patients with lesion of the genu were significantly older, and had a lower one-year extended Glasgow outcome scale in patients with corpus callosum injury (P<0.05) by bivariate analysis.

Conclusions: Lesion of the genu of the corpus callosum may be related to poor 1-year clinical outcome in patients with diffuse axonal injury.