2012 年 35 巻 1 号 p. 1-4
Objective: To determine the usefulness of plasma thrombin-antithrombin complex (TAT) level as early prognostic indicator in patients with isolated traumatic brain injury.
Methods: Fifty patients with isolated traumatic brain injury, who were measured TAT on admission, were included in this study. The Grasgow Coma Scale (GCS) score on admission, Glasgow Outcome Scale (GOS) score at discharge, plasma TAT level on admission were measured.
Results: Regardless of their GCS score on admission, plasma TAT levels on admission in patients with poor outcome were elevated significantly beyond their TAT levels in patients with good outcome. Moreover, patients with plasma TAT level on admission more than 800 ng/ml will have a poor outcome, and who would be likely to have a good outcome when their plasma TAT level on admission less than 400 ng/ml.
Conclusion: Plasma TAT level on admission may be used as predictors of outcome in patients with isolated traumatic brain injury irrespective of GCS score on admission.
