Particle Growth of Porous Spherical Hydroxyapatite by Two-step Phosphoration

Abstract

Low crystalline porous aggregates of hydroxyapatite (HAp) were prepared with colloidal calcium carbonate and phosphoric acid. Particle size and specific surface area of spherical HAp aggregates were controllable by two-step phosphoration with colloidal calcium carbonate and ammonium dihydrogenphosphate using low crystalline porous aggregates of HAp as seeds. The HAp aggregates after two-step phosphoration showed high crystallinity and thermal stability.