1,2-ジブロモ-1-フルオロエタンの脱臭化水素によるプロモフルオロエチレンの生成

抄録

The base-catalyzed elimination of hydrogen bromide from 1, 2-dibromo-1-fluoroethane yielding bromofluoroethylenes was carried out under various conditions (Table 1). In all cases, the formation of 1-bromo-2-fluoroethylenes [3] predominated over that of 1-bromo-1-fluoroethylene [2]. However, the use of stronger bases and protic solvents increased the ratio [2]/[3]. The results are discussed in reference to the plausible reaction mechanism (Fig.2). Of the Z and E isomers of [3], the former was present overwhelmingly due presumably to the thermodynamic stability.