Synthesis and Properties of Heparinized Nylon Membrane

Abstract

Nylon membrane having hydrophilic poly(oxyethylene) side chains and cationic N⁺ sites was synthesized by allowing hydrophilic epoxy compounds containing ethylene glycol moieties to react with dimethylaminated Nylon 6 membrane. Amounts of cations and water content were varied by changing reaction time or kind of epoxy compounds. The membrane was further heparinized to obtain antithrombogenic membrane. The amount of heparin released from the membrane increased with increase in the water content of the membrane. The amount of heparin released from the membrane prepared by using bifunctional epoxy compounds was much smaller than that by monofunctional compounds.