N-アセチル-DL-フェニルアラニンのペンチルアンモニウム塩の優先晶出法による光学分割
1986 年 1986 巻 1 号 p. 87-89
詳細
1986 年 1986 巻 1 号 p. 87-89
The optical resolution by preferential crystallization procedure of pentylammonium salt of N-acetyl-DL-phenylalanine (DL-PTA salt) has been studied. It was found by the comparision of the melting point, solubility and infrared spectrum of DL-PTA salt with those of the L-salt that DL-PTA salt is a racemic mixture. The optical resolution of DL-PTA s alt has been achieved in ethanol at 10 C for the racemic solution with degree of supersaturation of 120%. The L-PTA salt with optical purity of 95.7% was obtained in the degree of resolution of 98.2%. It was also possible to obtain both of D- and L-PTA salts with optical purity of over 90% by successively preferential crystallization. The N-acetyl-D- and -Lphenylalanine with optical purity of 99.6% was also obtained from the D- and L-PTA salts.
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