Synthesis of 4-(p-Toluidino)-2, 6, 7, 8-tetrahydroimidazo [1, 2-a] [1, 3, 5] triazin-2-one

Abstract

2-Chloro-4-(2-chloroethyl amino)-6-alkoxy-1, 3, 5-triazine reacted with p-toluidine at 120-130°C to give 4-(p-toluidino)-2, 6, 7, 8-tetrahydroimidazo[1, 2-a][1, 3, 5]triazin-2-one [5] in a good yield. But when the reaction was carried out at 80°C, the product was 2-(p-toluidino)4-(2-chloroethyl amino)-6-alkoxy-1, 3, 5-triazine [4]. Reaction of [4] with p-toluidine at 120-130°C did not give [5].