Abstract
The possibility of new electrochemical model reaction of cytochrome P-450 utilizing proton as an activator instead of acid anhydrides was studied with voltammetry and controlled potential electrolysis. (5, 10, 15, 20-Tetraphenylporphinato) iron (III) chloride (Fe(TPP)Cl) was used as a metalloporphyrin and N-methylimidazole was used as an axial ligand. Cyclic voltammetric studies on the effect of orga nic acids, used as a proton source, on the electrochemical behavior of Fe(TPP)Cl suggested that electrocatalytic cycle shown in Scheme 1 seems to be operating. Oxidative demethylation of N, N-dimethylaniline was performed under potentiostatic condition at -0.23 V (vs.SCE) in ethanol solution containing acetic acid under air atmosphere. N-Methylaniline, the oxidized product, was formed in 70% faradaic yield.
