Abstract
Background: AminoIndexTM Cancer Screening (AICS) is a novel cancer screening test that has been recently developed and is now in practical use for evaluating the probability of six types of cancers (lung, gastric, colorectal, prostate, breast and uterine/ovarian). The AICS test is based on “AminoIndex Technology”, which involves the multivariate analysis of the plasma free amino acid (PFAA) concentration between cancer patients and healthy controls. In this study, the validity of the AICS rank classification was assessed through a comparison of the distribution of AICS values for the developed theoretical pattern and the pattern seen in practice in Ningen-Dock.
Methods: The AICS test was assessed in 799 subjects (494 men, 305 women, average age: 59±11) at Mitsui Memorial Hospital. The frequencies of AICS rank C (recommended for detailed examination) and the distribution of AICS values were compared with the theoretical values defined during development.
Results: The frequencies of rank C in examinees of 6.8%, 3.0%, and 3.8% for AICS (colorectal), AICS (breast), and AICS (uterine/ovarian), respectively, were not significantly different from the theoretical frequency (5%), and the distribution of AICS values obtained in practice was equivalent to the theoretical values. The frequencies of rank C for AICS (lung), AICS (gastric), and AICS (prostate) in the examinees of 10.1%, 10.8%, and 11.3%, respectively, were significantly higher than the theoretical values, and there was a significant difference in the distribution of AICS values obtained in practice and the theoretical values.
Conclusion: As the frequencies of AICS ranks were virtually equivalent to the theoretical frequencies, our findings suggested that AICS would be applicable as a novel cancer screening test.
