2014 Volume 29 Issue 4 Pages 592-600
Objective: We adopted a simultaneous, parallel approach in which upper gastrointestinal tract endoscopy (GE) and a glucose tolerance test based on urinary myoinositol (UMI) measurement were performed in a single-day health check-up, and examined the possibility of using it in screening for patients with impaired glucose tolerance.
Methods: The subjects were 10 volunteers who underwent a 75-gram oral glucose tolerance test, and were classified into the glucose tolerance categories according to WHO criteria (1998) before the health check-up. Subjects classified into the normal glucose tolerance category whose blood glucose level measured one hour after the glucose load exceeded 180 mg/dL were defined as pre-borderline. Their urine samples were collected before the glucose load and two hours later to measure UMI. On the day of the health check-up, they were subjected to the glucose load after urine sampling in the fasting state early in the morning. Then, they underwent GE. Two hours after the glucose load, they underwent urine sampling again. UMI was expressed as the difference between the creatinine-corrected UMI concentrations obtained before and after the glucose load.
Results: There was no influence on the image observed in GE as long as at least 60 minutes had passed since the glucose load. The results of UMI measurement performed after endoscopy were similar to those for measurement performed previously.
Conclusions: These results demonstrated the feasibility of performing the glucose intolerance test by means of UMI measurement and endoscopy simultaneously, in parallel in a single-day health check-up.
