2014 Volume 29 Issue 4 Pages 601-609
Objective: For the purpose of health guidance concerning chronic kidney disease (CKD), a risk factor for end-stage renal disease and cardiovascular disease, we examined associations between changes in eGFR and various factors in research that compared data obtained at baseline and 9 years later.
Methods: The subjects were 7,550 persons (4,074 males, 3,476 females; average ages 48.3 years, and 47.8 years, respectively) who had undergone a health check-up in both 2003 and 2012 at our facility. Analysis was conducted using eGFRs for 2003 and 2012 and various baseline data in 2003. Regarding changes in eGFR over time, GFR divisions were used in place of severity of CKD.
Results: At -6.4 mL/min/1.73 m2 in men and -7.2/min/1.73 m2 in women, there had been a significant drop in eGFR. Regarding individual eGFR divisions, G3a had increased by 9.6% in 2012. Regarding change in eGFR, age, eGFR (the higher the greater), urinary protein of 1+ or greater, hypertension and diabetes in 2003 were significant progressive factors, while female gender, serum albumin level, hemoglobin content and HDL-C were inhibitory factors. In logistic regression analysis on whether there had been deterioration in GFR division or not, age, eGFR, urinary protein of 1+ or greater, hypertension, diabetes and uric acid in 2003 were significant progressive factors, while female gender, serum albumin level, and hemoglobin content were inhibitory factors.
Conclusion: Analysis of factors influencing decline in eGFR and progression in eGFR division showed that there were several independent factors other than aging influencing this. In order to prevent progression of CKD, health guidance considering such factors in addition to underlying diseases is necessary.
