Abstract
Objective: To examine changes in eGFR and eGFR-associated risk factors in order to provide proper health guidance to health check-up examinees.
Methods: The trends in eGFR and the associated risk factors were compared between two groups of health check-up examinees: (i) examinees of comprehensive health checkups provided by health insurance societies or mutual aid associations, or of those who applied for them personally (comprehensive examinees) and (ii) examinees of preventive check-ups for lifestyle-related diseases provided by the Japan Health Insurance Association or those of health check-ups prescribed in the Ordinance on Industrial Safety and Health (simplified examinees). Other risk factors influencing changes in eGFR were also investigated separately in men and women. In addition, trends in eGFR and factors causing deterioration in eGFR were evaluated in individuals whose eGFR was less than 60 mL/min/1.73m2.
Results: Values of eGFR tended to be lower in comprehensive examinees in their 30s. The proportions of high BMI (≥ 25 kg/m2), high SBP (≥ 140 mmHg), high DBP (≥ 90 mmHg), high FPG (≥ 100 mg/dL), and current smoking status tended to be lower in comprehensive examinees than in simplified examinees. Changes in eGFR were inversely correlated with changes in serum uric acid concentration. High urinary sugar or protein, and treatment for hypertension, dyslipidemia, hyperuricemia, or kidney disease did not seem to influence the deterioration in eGFR in our health check-up examinees.
Conclusion: While lifestyle improvement has little influence on changes in eGFR, the associated risk factors, such as high BMI, high SBP, high DBP, and active smoking status, can be managed through proper health guidance.
