Abstract
Objective: The purpose of this study was to measure the frequency of non-ampullary duodenal epithelial tumors (NADET) and describe their clinical characteristics in healthy subjects in whom tumors were identified.
Methods: We performed esophagogastroduodenoscopy (EGD) in 32,542 subjects during health check-ups from 2016 to 2018. We selected subjects diagnosed with NADET by pathological examination and investigated the clinical characteristics.
Results: Twenty subjects were diagnosed with NADET, corresponding to an endoscopic detection frequency of 0.061%. The male-to-female ratio among the 20 cases was 13:7, and the mean age was 56.2 ± 11.4 years (range: 35–79 years). In 15 subjects, (75.0%) lesions were 10mm or less in diameter. The most common macroscopic type was Ⅱ a (11 lesions, 55.0%). Fifteen lesions (75.0%) were either entirely white or had white margins. Thirteen patients underwent endoscopic resection, and one had surgery. Two cases (10.0%) were diagnosed with intramucosal cancer by analysis of the resected specimen.
Conclusions: The frequency of NADET found on EGD during health check-ups was 0.061%, and 2 out of 20 cases (10.0%) were intramucosal cancers. Endoscopists who perform screening using EGD should examine the descending part of the duodenum as far as possible, and check for tumors of small sizes.
