Bone Turnover Markers and Risk Factors Associated with Osteoporosis and Decreased Bone Mass

抄録

Objective: The first aim of this study was to identify risk factors associated with osteoporosis and decreased bone mass in the general Japanese population. The second was to elucidate the relationship between bone mineral density and bone turnover markers.

Materials and Methods: We analyzed bone mineral density (BMD) and bone turnover markers - such as bone-specific alkaline phosphatase (BAP), urinary deoxypyridinoline (DPD) and N-terminal crosslinking telopeptide of type I collagen (NTX) - in 238 subjects who visited the Department of General Medicine, National Center for Global Health and Medicine from March 2005 through March 2007 for a Ningen Dock-style annual health check-up. Risk factors associated with osteoporosis and decreased bone mass were evaluated using multivariate logistic regression analysis, and the differences in BMD and bone turnover markers were examined between subjects with and without osteoporosis.

Results: Factors associated with osteoporosis were age, gender (female) and low BMI, and specifically in female subjects menopause, high serum level of total cholesterol and large alcohol intake (p<0.05). BMD was strongly correlated with bone turnover markers. (NTX : R= –0.44, p<0.0001, DPD: R= –0.42, p<0.0001).

Conclusion: Bone turnover markers were useful for estimating BMD. High serum level of total cholesterol and large alcohol intake were risk factors for osteoporosis.