Ningen Dock International
Online ISSN : 2187-8080
Print ISSN : 2187-8072
Original Article
Helicobacter pylori Antibody Titers in the High Normal Range Include Cases of H. pylori Infection in Patients with H. pylori-related Gastritis
Kyoko ItoTomohiro Kato
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ジャーナル フリー

2019 年 6 巻 1 号 p. 50-55

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Objective: Helicobacter pylori (Hp) infection plays a critical role in gastric neoplasm pathology. Detecting Hp and Hp-related gastric diseases is important for gastric cancer prevention. Recent studies showed that Hp infection was missed to be diagnosed in some patients with atrophic gastritis when serum anti-Hp antibody enzyme immunoassay detection tests (Hp tests) were used. Here, we review the results of Hp testing over a 5-year period in patients with Hp-related gastritis.

Methods: We included 4,319 subjects who underwent optional Hp testing at our institute during Ningen Dock from 2012 to 2016. We investigated the prevalence of Hp positivity in spite of technically negative antibody titers of 3-9 (high negative) in Hp tests in Hp-related gastritis. Single and multiple logistic regression analyses were performed to identify factors associated with Hp infection among a total of 26 potential factors.

Results: The prevalence rates of positive and high negative Hp results were 31.6% and 11.4%, respectively, with no differences between the sexes. In patients with Hp-related gastritis, the prevalence rates of positive and high negative Hp results were 62.5% and 14.2%, respectively. Age, anemia, increased white blood cell count, and higher aspartate aminotransferase (AST) levels were associated with Hp infection (p <0.05).

Conclusions: We identified possible Hp infection in patients with Hp-related gastritis who tested negative for serum anti-Hp antibodies. Anemia was a factor associated with Hp infection, which is consistent with previous studies. We also found that elevated AST levels were associated with Hp infection, a novel finding. Further studies are needed to clarify the pathology.

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© 2019 Japan Society of Ningen Dock
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