抄録
Background: We aimed to evaluate the reliability of different combinations of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and 2-h post-challenge glucose level (2-h PG) after a 75-g oral glucose tolerance test (75g OGTT) for diagnosing “prediabetes type,” “diabetes type,” and “normal type.”
Methods: All participants underwent a 75g OGTT and HbA1c measurements. Definitions of “normal type,” “prediabetes type,” and “diabetes type” for FPG were <110 mg/dL, 110≤ FPG <126 mg/dL, and 126 mg/dL ≤ FPG, respectively; those for 2-h PG were <140 mg/dL, 140 mg/dL ≤2-h PG <200 mg/dL, and 200 mg/dL ≤, respectively, while those for HbA1c were ≤6.2%, 6.2< HbA1c ≤6.5%, and 6.5%<, respectively. The prevalence of “prediabetes type,” “diabetes type,” and “normal type” was estimated using seven different combinations, namely, “HbA1c+FPG or HbA1c+2-h PG,” “HbA1c+2-h PG,” “HbA1c+FPG,” “HbA1c alone,” “FPG+2-h PG,” “2-h PG alone,” and “FPG alone.”
Results: The diagnosis of “prediabetes type” required, at minimum, FPG and 2-h PG values, and the inclusion of HbA1c helped minimize day-to-day variation and false positives in FPG and 2-h PG values. In contrast, the diagnosis of the “diabetes type” could be made using “a combination of HbA1c+2-h PG” instead of “HbA1c+FPG or HbA1c+2-h PG,” while the combination of “HbA1c+FPG or HbA1c+2-h PG” appeared reliable for diagnosing “normal type.”
Conclusion: “A combination of HbA1c+FPG or HbA1c+2-h PG” is recommended for the diagnosis of “prediabetes type,” “diabetes type,” and “normal type.”
