Autoradiographic Studies on Percutaneous Absorption and Reservoir of 17α-Desoxymethasone

Abstract

1. The percutaneous absorption of 17α-desoxymethasone and its reservoir in the skin were investigated by means of an autoradiography.
2. It was noted in subjects applied under plastic film by 30-minute, 2-hour, 8-hour and 24-hour that a considerable amount of autoradigraphic silver grains deposited in the epidermis and appendages of the skin.
3. The drug reservoir in the skin was observed even 24 hours after the removal of the drug topically applied.
4. The above-mentioned observations suggest that this drug is absorbed into the skin rapidly after topical application, and that the effect of the drug persists even after its removal due to its reservoir in the skin.