Abstract
A 19-year-old woman developed sebaceous epithelioma in a nevus sebaceus which had been situated on her nose since birth. The authors supposed that sebaceous epithelioma is differentiated from sebaceous adenoma and basal cell epithelioma histopathologically. The development of sebaceous epithelioma derived from nevus sebaceus might be accelerated by radiotherapy and solid carbon dioxide therapy performed in infancy. We recognized that the early removal of nevus sebaceus is a very beneficial treatment.