Anti-DNA Antibodies of Various Skin Diseases

—Mainly on Systemic Lupus Erythematosus—

Abstract

Anti-DNA antibodies in patient sera of various skin diseases and in normal sera, were determined by a hemagglutination test using erythrocytes labelled with both native and denatured DNA. High anti-DNA antibody titer was shown in active systemic lupus erythematosus (SLE) and it was more elevated during the clinically acute period. The anti-DNA antibody titer of well controlled SLE was under 160 fold dilution of the sera. From the above results, it is considered the test is a useful examination to diagnose SLE and to evaluate the course of the disease.