Abstract
Three cases of genital Paget’s disease were observed by electron microscopy. In two cases, Paget’s cells included the presence of secretory granules or glycogen granules and formed lumens and intercellular canaliculi. Desmosomes were small and poorly developed. These findings were suggested as an eccrine sweat gland origin or differentiation toward eccrine apparatus. In the other case, pleomorphic mitochondria, ribosomes and vacuoles were prominent in the cytoplasma of Paget’s cells. Desmosomes were poorly developed and tonofilaments or glycogen granules were difficult to detect in the cytoplasma of Paget’s cells. Thus, we could not determine the origin of Paget’s cell in this case.
