Burn Scar Carcinoma Associated with a Marked Hematogenous Metastasis

Abstract

A 40-year-old man, who had been burned at age 5 years, had a squamous cell carcinoma on the right popliteal region associated with metastasis to the femoral lymphnodes. Widespread hematogeneous metastasis became evident soon after excision of the carcinomatous tissues. A marked hypercalcemia and granulocytosis appeared at the end stage. An excess secreting parathyroid hormone (PTH) or colony stimulating factor (CSF) from the tumor cell was considered, but there was no evidence of high levels of PTH or CSF in the blood and urine. Surgery and radio- and immunotherapy proved to be ineffective and he died about 10 months after onset of the disease.