Efficacy Judgement of Topical Corticosteroids

Abstract

We reviewed the effect of topical application of corticosteroid both in cream and ointment form (halcinonide cream, ointment). Such was applied in cases of erythema induced in human volunteers by 1.5 MED ultraviolet rays.
1) The halcinonide cream had a more rapid effect than the ointment, however, the former caused a characteristic change of the skin i. e., crepe-like appearance of the skin.
2) In general, the efficacy of halcinonide ointment was better than that of halcinonide cream and in the depot effect of the corticosteroid, the ointment was superior to the cream.
3) The corticosteroid effects of every two hours’ application and that of every four hours’ application were much the same and every eight hours’ application was less effective.