Cutaneous Lymphoma (B Cell Lymphoma) in Childhood

—Report of a Case and Review of the Japanese Literature—

Abstract

A 7-year-old Japanese boy had a cutaneous tumor on the right forehead following head trauma. Biopsy of the tumor showed infiltrates characteristic of lymphoblastic lymphoma. Results of immunohistochemical studies revealed that malignant cells had Ia, B4 and CALLA antigens on the cell surface, but not B1 antigen and cytoplasmic immunoglobulins, which are characteristics of immature B cells between lymphoid stem cells and pre-pre B cells. The patient was put on a modified LSA₂L₂ regimen for childhood non-Hodgkin’s lymphoma and complete remission was attained. Cases of cutaneous lymphoma in Japanese children are reviewed.