Induction by Griseofulvin of Experimental Protoporphyria in Hairless Mice

Abstract

To investigate whether experimental protoporphyria can be induced in hairless mice, feed containing 0.5% griseofulvin (GF) was given to hairless Hos HR/De strain mice for two to four months. Protoporphyrin levels in the erythrocytes and the liver were extremely elevated, that is, protoporphyria was induced in these mice. Acute skin changes such as erythema, edema, blister and crust formation appeared after exposing the hairless mice with protoporphyria to 400 nm of light, using a metal halide lamp. Thus, hairless mice of the HR/De strain can serve as a valid model of protoporphyria. These mice are useful for macroscopic and histopathological observations of skin changes, and for photosensitivity experiments.