67-65 Kd and Their Pair Keratins: Specific Roles in the Formation of Horny Keratin Fiber and Abnormality in the Hereditary Palmo-plantar Keratosis

Abstract

67-65 Kd and their pair keratins produced in suprabasal epidermal cells have specific roles in the formation of horny keratin fiber, mainly by developing V domains in their molecules. The abnormal gene expression of these keratins in recessive and dominant hereditary palmo-plantar keratosis is indicative of these specific roles.