Abstract
A case of cutaneous myxoma in a 67-year-old male on the left arm was reported. A microscopic examination of skin tumors showed a thin epidermis, edematous dermis, a full of mucinous matrix in the dermis and either stellate cells or ovale cells in the dermis. An ultrastructual examination disclosed predominantly fibroblast-like cells with a prominent rough endplasmic reticulum, microfilamentous material, and pynocytotic vesicles, together with a mixture of amorphous and granular material and collagen fibers in the extracellular spaces. Histochemical techniques yieled the following results: a positive dialyzed iron reaction, however with either a complete or almost complete removal of this positive reaction by prior digestion with storeptmyces hyaluronidase; a positive toluisin blue staning at pH 3.5, yet a negative periodic acid-Schiff reaction. These results indicate the presence of a large amount of hyaluronic acid in the mucinous matrix. A biochemical study also supported these results.
