Abstract
A 41-year-old Japanese man with multiple endocrine neoplasia (MEN) type 2B, who also had medullary thyroid carcinoma presented with asymptomatic multiple neuromas on the lips, buccal mucous membrane, tongue and palpebral conjunctiva which developed during his childhood. The physical features of this patient were quite characteristic because of his thickened lips, swollen eyelids, hyperextensibility of the peripheral joints, and Marfan’s syndrome-like physique. A similar physical constitution was also seen in the patient’s mother and a younger brother.
