The Nishinihon Journal of Dermatology
Online ISSN : 1880-4047
Print ISSN : 0386-9784
ISSN-L : 0386-9784
Clinical Case Reports
A Case of Acute Monocytic Leukemia with Skin Infiltration
Makiko IGUCHITakahiko TSUNODAKenichi ISHIZAWAFumiaki YUDAKyoko OHARA
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1999 Volume 61 Issue 1 Pages 59-61

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Abstract
A 76-year-old male was referred to us with a half month history of an asymptomatic erythematous lesion on his trunk. An increased percentage of monocytes (26%), promonocytes (10%), and monoblast (7%) were seen in a peripheral blood smear. Atypical cells were positive for CD 68 and lysozyme. Biopsy specimens showed the presence of a grenz zone consisting of normal connective tissue separating the normal epidermis from a diffuse infiltrate of atypical mononuclear cells in the upper half of the dermis. Atypical cells in the dermis had basophilic convoluted nuclei and eosinophilic cytoplasm. These cells were also found in the gingiva and bone marrow. The eruption disappeared after 7 days of chemotherapy for leukemia.
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© 1999 by Western Japan Division of JDA
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