Abstract
We report a case of secondary syphilis exhibiting unusual clinical manifestations. A 52-year-old man presented with spreading erythema with papular elements on his extremities and trunk. Results of serology for syphilis using the Treponema pallidum latex immunoassay were positive. Examination of a biopsy specimen from the dorsum of the right hand revealed sarcoidal granulomas in the superficial and deep dermis in addition to the banal features of syphilis such as psoriasiform epidermal hyperplasia, capillary proliferation, and plasmacytic infiltrate. Caseation necrosis was not observed. Although we did not find Treponema pallidum from the tissue, we made the diagnosis of secondary syphilis based on serological, pathological and treatment course.
