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Volume 68 (2006)
- Issue 6 Pages 607-
- Issue 5 Pages 477-
- Issue 4 Pages 351-
- Issue 3 Pages 235-
- Issue 2 Pages 125-
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Volume 68, Issue 3
Displaying 1-18 of 18 articles from this issue
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Color Atlas
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Tessin WATANABE, Koji TANIGUCHI, Toshiyuki AKI, Osamu YAMAMOTO2006 Volume 68 Issue 3 Pages 235-236
Published: 2006
Released on J-STAGE: July 31, 2006
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Tadashi ISHIKAWA, Shinji KOMADA, Sakuhei FUJIWARA2006 Volume 68 Issue 3 Pages 237-238
Published: 2006
Released on J-STAGE: July 31, 2006
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Mini Review
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—disease entity for sick house syndrome and its difference from chemical sensitivities—Yukio SASAGAWA2006 Volume 68 Issue 3 Pages 239-243
Published: 2006
Released on J-STAGE: July 31, 2006
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Clinical Case Reports
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Takeo SHIGA, Maki YOKOGAWA, Koji OGATA, Tatsumi CHIJIWA, Masafumi KAWA ...2006 Volume 68 Issue 3 Pages 244-247
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSA 34-year-old man had gotten tattoos on the right chest, back and upper arm three years previously. He presented twice with slightly elevated plaques at the site of red tattoos preceded by right axillary lymph node swelling and common cold symptoms that included high fever and sore throat. A skin biopsy specimen obtained from a lesion showed infiltration of numerous CD68 positive histiocytes around the tattoo dye granules in the dermis. Patch testing revealed positive reaction against mercury (II) chloride, which was the main component of his red tattoo dye. Skin lesions improved within one week of oral administration of prednisolone (30 mg/day) and topical applications of corticosteroid. Since discontinuation of treatment, no signs of recurrence have been observed. We consider that viral or bacterial infection initiated the development of his allergic mercury dermatitis.View full abstractDownload PDF (1346K) -
Shuko OKADA, Takashi MASU, Takahiko TSUNODA, Ryuhei OKUYAMA, Setsuya A ...2006 Volume 68 Issue 3 Pages 248-250
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSA 38-year-old Japanese man had been treated with Fiblast® spray, a product of recombinant human basic fibroblast growth factor, for a skin ulcer after open reduction of a fractured calcaneum. The skin ulcer did not improve well and was associated with desquamative erythema. We observed a positive reaction on patch test against benzalconium chloride, which is included as a preservative in Fiblast® spray. Benzalconium chloride is known to provoke contact dermatitis. We should exercise caution with Fiblast® spray because of its potential to cause contact dermatitis.View full abstractDownload PDF (491K) -
Akira HASHIMOTO, Ryuhei OKUYAMA, Satoshi HASEGAWA, Hiroshi WATANABE, T ...2006 Volume 68 Issue 3 Pages 251-255
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSDermatomyositis is frequently associated with opportunistic infection, which is caused by various organisms including cytomegalovirus, Candida albicans, and Pneumocystis carinii. We describe 2 cases of dermatomyositis with cytomegalovirus infection. Case 1: A 67-year-old Japanese woman had visited us in Octorber 2002 for erythema with myalgia on her trunks. Her condition was diagnosed as dermatomyositis, which was treated with prednisolone at first but did not respond well. In addition, we used cyclophosphamide for her therapy. In February 2003, pneumonia developed, and cytomegalovirus and Aspergillus were detected. Although gancyclovir and γ-globulin were immediately started, her general condition worsened and she died on March 2003. In the autopsy, there were histological changes specific to cytomegalovirus infection in the lung. Case 2: A 72-year-old Japanese woman had visited us in November 2004 for erythema with myalgia distributed on her face and trunk. She was diagnosed as dermatomyositis and treated with prednisolone, to which erythema and myalgia responded well. When the daily prednisolone had been gradually decreased to 35mg, liver dysfunction suddenly developed together with pyrexia. Gancyclovir was administered because of the presence of cytomegalovirusemia. Two weeks after the administration, her general condition improved. Both cases suggested the importance of careful examination and appropriate therapy for managing cytomegalovirus infection during the treatment of dermatomyositis.View full abstractDownload PDF (922K) -
Yumi MURASE, Jun KURODA, Yoshinao MURO, Yasushi TOMITA2006 Volume 68 Issue 3 Pages 256-259
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSThe patient was a 52-year-old male who from the age of 50 years had had interstitial lung disease. After treatment with steroid and cyclosporine, he developed Carinii pneumonia, which resolved although there was no remission of the interstitial lung disease. A year later he developed scleroderma with symptoms of myositis. When respiratory symptoms additionally became evident, he was treated with an intravenous pulse of cyslophosphamide every 3 weeks in combination with daily oral prednisolone and azathioprine. After 6 courses of pulse treatment, respiratory symptoms improved as did various indicators such as PaO2, SP-D, %VC, LDH, CK, aldolase, and the skin score. No adverse effects were experienced during the cyclophosphamide treatment. Our experience suggests that pulse therapy with cyclophosphamide can be recommended for systemic sclerosis related to interstitial lung disease.View full abstractDownload PDF (635K) -
Masahisa SHINDO, Osamu YAMAMOTO, Yoshitaka HAGARI2006 Volume 68 Issue 3 Pages 260-262
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSAn 8-year-old Japanese girl presented with a 1-month history of eruptions on her limbs. The eruptions were resistant to several medications, and the patient was referred to our clinic with many irregular, well-defined, dark brown and slightly elevated plaques with pityriasic scales on her legs. Histology revealed infiltration of numerous eosinophils from the dermis to the subcutaneous fat level with prominent flame figures. Topical steroid and an oral anti-allergy agent were not effective. Oral corticosteroid was administered and resulted in an improvement of the disease. Eosinophilic cellulitis developing in childhood is very rare, and only 2 cases have been reported in Japan. Eruptions in all 3 cases, including the present case, had developed on the legs. Two cases, including our case, had atopic dermatitis, but the clinical significance of the association of these two diseases is still unknown at present.View full abstractDownload PDF (864K) -
Monji KOGA, Takahiro YAMAGUCHI, Yumiko KUBOTA, Juichiro NAKAYAMA, Akih ...2006 Volume 68 Issue 3 Pages 263-265
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSWe report two cases of a painful solitary glomus tumor on the trunk. Case 1 was a 61-year-old man with a reddish painful nodule on the left infrascapular region. Case 2 was a 64-year-old man with a blue painful nodule on the left shoulder. Both tumors were successfully excised under local anesthesia without recurrence. Based on histological findings, we diagnosed the former as a “glomus tumor proper” and the latter as a “glomangioma”. Tumor cells in both cases were positive for vimentin and α-smooth muscle actin immunohistochemically. Furthermore, a few strands of nerve fibers with positive staining for S-100 protein were found in and around both tumors, which seemed to be the main cause of the pain.View full abstractDownload PDF (919K) -
Akari TASHIRO, Shinichi IMAFUKU, Hiromaro KIRYU, Mari NAKAMORI, Satosh ...2006 Volume 68 Issue 3 Pages 266-268
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSWe report a case of secondary syphilis exhibiting unusual clinical manifestations. A 52-year-old man presented with spreading erythema with papular elements on his extremities and trunk. Results of serology for syphilis using the Treponema pallidum latex immunoassay were positive. Examination of a biopsy specimen from the dorsum of the right hand revealed sarcoidal granulomas in the superficial and deep dermis in addition to the banal features of syphilis such as psoriasiform epidermal hyperplasia, capillary proliferation, and plasmacytic infiltrate. Caseation necrosis was not observed. Although we did not find Treponema pallidum from the tissue, we made the diagnosis of secondary syphilis based on serological, pathological and treatment course.View full abstractDownload PDF (1189K) -
Yumiko KUBOTA, Juichiro NAKAYAMA2006 Volume 68 Issue 3 Pages 269-273
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSWe report a case of ginkgo seed poisoning after eating more than 50 ginkgo-nuts. The patient was a 62-year-old woman who had contact dermatitis caused by ginkgo fruit. She had been eating 5-10 ginkgo-nuts every day for 40 years. She had had lung cancer for 20 months. Temporary remission was achieved by chemotherapy, but bone and brain metastases appeared 10 months ago. She had been taking gefitinib for 9 months. She developed erythema with itching of the lower legs and facial edema a week after peeling ginkgo fruit in October 2004. The eruptions were improved by oral and topical steroid treatment. On October 11, she developed facial edema, transient unconsciousness and sensory aphasia several hours after eating more than 50 ginkgo-nuts. Physical examination on admission revealed no abnormality. Encephalitis or brain metastasis of lung cancer was excluded by brain CT, MRI, EEG and lumbar puncture. We suspected ginkgo seed poisoning. Her sensory aphasia improved gradually after administration of vitamin B6, and she was discharged 2 weeks later. Open patch testing (PT) with ginkgo fruit revealed a positive reaction after 48 hours, and the positive reaction continued for 3 weeks. Closed PT with urushiol and ginkgo leaf revealed positive results. Her first eruption was diagnosed as allergic contact dermatitis caused by ginkgo fruit. Ginkgo seeds are popular food items in Japan, Korea and China. Ginkgo seed poisoning usually occurs in children, who exhibit repetitive seizures that can be fatal. Prompt administration of pyridoxal is effective because this poisoning is caused by 4 methoxypyridoxine contained in ginkgo seed. Early detection and treatment of this ginkgo seed poisoning case was possible due to the preceding contact dermatitis caused by ginkgo fruit.View full abstractDownload PDF (821K)
Therapy
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Akira TAKAHASHI, Naoya YAMAZAKI, Akifumi YAMAMOTO, Kouji YOSHINO, Kenj ...2006 Volume 68 Issue 3 Pages 274-279
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSSince the concept of sentinel node biopsy (SNB) was introduced into the treatment of cutaneous malignant melanoma, many reports have come to be seen about the usefulness in Europe and America. In Japan, surgeons in many institutions started performing dye-guided SNB on patients with cutaneous malignant melanoma around 1997, and we also initiated the procedure primarily on patients with inguinal lymph nodes as a regional lymph node. From April 2002 onward, we performed preoperative lymphoscintigraphy and intraoperative gamma probe detection in combination with a dye method, which demonstrated a high sentinel node identification rate of 95%. The identification rates of individual regional lymph nodes were 97% for inguinal lymph nodes, 96% for axillary lymph nodes, and 89% for cervical lymph nodes, which were significantly higher than those achieved by the dye method alone. The combination of dye and RI is essential for accurate identification of sentinel nodes, and many institutions should preferably establish the standards for sentinel node navigation surgery with the use of dye and RI.View full abstractDownload PDF (955K) -
Shoji TANIGUCHI, Mamori TANI, Takashi YAMANAKA, Takeshi KONO, Shigetos ...2006 Volume 68 Issue 3 Pages 280-283
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSAlthough toenail onychomycosis is not a life-threatening disease, it is not just a cosmetic problem and can have serious adverse effects on the quality of life (QOL) of patients. In this study, we evaluated the impact of itraconazole pulse therapy on the QOL of patients with toenail onychomycosis. A total of 30 patients were asked to complete a QOL questionnaire (Skindex 29) unaided in the waiting room before treatment and on the last follow-up visit (week 48). The results indicate that treatment with itraconazole not only improves toenail onychomycosis clinically and mycologically, but also significantly improves patients' QOL.View full abstractDownload PDF (302K) -
Hidetoshi TAKAHASHI, Hajime IIZUKA2006 Volume 68 Issue 3 Pages 284-287
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSBepotastine besilate has been used for various pruritic skin disorders as an antisedative antihistamine. In this study we analyzed the effect of bepotastine besilate on the itch sensation and sedation in 91 patients with pruritic skin disorders. A visual analogue scale (VAS) score determined by the patient was used for evaluation. After a week of administration of bepotastine besilate, the VAS score for itch sensation was significantly reduced, an effect that continued for 8 weeks. In contrast, the VAS score for sedation level was not significantly affected by bepotastine besilate administration. These results indicate that bepotastine besilate is effective for pruritic skin disorders without inducing a considerable sedative effect.View full abstractDownload PDF (260K) -
Katsuyuki TAKEDA, Tomohiro YOKOTA, Takeshi IKEMOTO, Hiroshi KAKISHIMA, ...2006 Volume 68 Issue 3 Pages 288-292
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSA double-blind test was performed on human subjects to determine the efficacy of formulations containing 0.5% Magnolignan® (5,5'-dipropyl-biphenyl-2,2'-diol) for treatment of UV-induced pigmentation. Two adjacent test areas were selected on the inside of the upper arm of 43 subjects. A significant difference in the pigmentation score was observed after 3 weeks of application of a formulation containing 0.5% Magnolignan® in comparison with a placebo. Furthermore, the improvement in ΔL values were significantly different after 3 weeks compared with the placebo. No unfavorable skin reaction such as irritation, etc., was observed during the test period. In conclusion, the formulation containing 0.5% Magnolignan® was found to be safe and effective for topical application in treating UV-induced pigmentation. These data indicate that Magnolignan® is an effective whitening ingredient that can be used in cosmetics.View full abstractDownload PDF (421K) -
Katsuyuki TAKEDA, Seiji ARASE, Yoshiaki SAGAWA, Yuko SHIKATA, Hiroyuki ...2006 Volume 68 Issue 3 Pages 293-298
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSThe lightening effects of Magnolignan® (5,5'-dipropyl-biphenyl-2,2'-diol) on hyperpigmentation on the face, such as melasma, senile lentigo, etc., were studied in 51 female patients. The formulation containing 0.5% Magnolignan® was topically applied to pigmented areas on the face for 6 months. The score representing the degree and area of pigmentation was significantly improved during the test period. The ΔL values also were significantly improved after 6 months. Results of a questionnaire given after the 6-month test period indicated that a large proportion of subjects strongly felt that the condition of the various pigmentations had improved and that the formulation was of high quality for daily use. The topical application of 0.5% Magnolignan® was confirmed to be effective in lightening not only pigmented skin lesions but also non-pigmented healthy skin. No unfavorable skin reaction was observed during the test period. In conclusion, the formulation containing 0.5% Magnolignan® was found to be safe and effective for topical application to treat various skin pigmentations.View full abstractDownload PDF (747K) -
—A Comparative Study of Maxacalcitol Ointment and High-concentration Tacalcitol Ointment—Norito KATOH, Saburo KISHIMOTO2006 Volume 68 Issue 3 Pages 299-304
Published: 2006
Released on J-STAGE: July 31, 2006
JOURNAL RESTRICTED ACCESSIn 18 patients with psoriasis vulgaris, a bilateral-paired comparison study was conducted to evaluate the efficacy of maxacalcitol ointment 25μg/g (Oxarol® Ointment) and tacalcitol ointment 20μg/g (Bonalfa® High Ointment). As a rule, maxacalcitol ointment 25μg/g was applied once daily on weekdays and twice on each Saturday and Sunday, and tacalcitol ointment 20μg/g was applied once daily on each day during the study period. The ointments were applied for a period of 8 weeks to different sides of the body in a symmetrical manner. The percentage of patients with a moderate or superior alleviation at the time of final evaluation was 55.6% and 33.3% on the side treated with maxacalcitol ointment 25μg/g and tacalcitol ointment 20μg/g, respectively. Thus, both ointments exerted high efficacy. When overall improvement was compared between the two sides treated with different ointments, the outcome was better on the maxacalcitol-treated side in 33.3% of patients and on the tacalcitol-treated side in 11.1% of patients. These results suggest that topical treatment with maxacalcitol ointment 25μg/g (once daily on weekdays and twice on Saturdays and Sundays) is a useful treatment of psoriasis.View full abstractDownload PDF (689K)
Dermatologists around the World
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2006 Volume 68 Issue 3 Pages 313-314
Published: 2006
Released on J-STAGE: July 31, 2006
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