Abstract
Bepotastine besilate has been used for various pruritic skin disorders as an antisedative antihistamine. In this study we analyzed the effect of bepotastine besilate on the itch sensation and sedation in 91 patients with pruritic skin disorders. A visual analogue scale (VAS) score determined by the patient was used for evaluation. After a week of administration of bepotastine besilate, the VAS score for itch sensation was significantly reduced, an effect that continued for 8 weeks. In contrast, the VAS score for sedation level was not significantly affected by bepotastine besilate administration. These results indicate that bepotastine besilate is effective for pruritic skin disorders without inducing a considerable sedative effect.
