Abstract
Heterotransplantation of a human liposarcoma in nude mice was used to evaluate the efficiency of Menogaril as a new antitumor agent. The in vivo model was successfully produced by tranplantation of cloning cells from a human liposarcoma cultured cell line. The cultured layer was established from a myxoid liposarcoma. The drug was administered orally to the models by 3 different methods. The administration group demonstrated marked growth inhibition of the tumors. In conclusion, administration of Menogaril was effective in the in vivo model.
