EXPERIMENTAL STUDY ON THE TEMPORARY OCCLUSION OF THE HEPATIC AFFERENT BLOOD SUPPLY DURING HYPOTHERMIA
1959 Volume 56 Issue 10 Pages 799-817
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1959 Volume 56 Issue 10 Pages 799-817
To accomplish hemostasis and prevent blood loss during hepatic surgery, fifty-threedogs were subjected to the temporary occlusion of the hepatic afferent blood supply forone hour. And four dogs were subjected to the subtotal hepatectomy following the hepaticafferent occlusion for one hour during hypothermia. Results obtained in the experimentare as follows:
1) When dogs were subjected to the occlusion of the hepatic afferent blood supply forone hour, the portal pressure elevated, and the arterial blood pressure fell immediatelyafter the occlusion, and then, the circulating blood volume decreased, and pulses becameirregular, and hematocrit elevated. After its release, blood sugar and serum potassium.elevated.
2) In the normothermic series, four of sixteen dogs survived following one hour occlusion. Survials showed no remarkable changes by liver function tests and histopathologicstudies.
3) In the hypothermic series, the portal pressure, the arterial pressure, the circulatingblood volume, pulses, hematocrit, blood sugar, serum potassium, and B. S. P. clearance: were examined.
Though there were the same tendencies in the hypothermic series as in the normothermic, changes in the hypothermic were usually somewhat lower. However, correlations.between the degree of changes and prognosis has not always been proved. These changesmust be examined in the future.
4) In the hypothermic series cooled to the rectal temperature of 27°C, twenty two ofthirty seven dogs survived following one hour occlusion. Survivals showed no remarkablechanges by liver function tests and histopathologic studies.
5) When dogs were subjected to the subtotal hepatectomy following the hepatic afferentocclusion for one hour during hypothermia, one of four dogs survived. At its autopsytwo months after the surgery, liver regeneration was abundunt, and there were noremarkable changes by liver function tests and histopathologic studies.
6) Aided by transfusion, blood transfusion, antibiotics, and the proceeding of surgicaltechnique, the hepatic afferent occlusion during hypothermia would be applied clinicallywith safety.
